1. In AML, though, a single myeloblast accumulates genetic changes which "freeze" the cell in its immature state and prevent differentiation.

2. MyeloBlastoma: [ mi″ĕ-lo-blas-to´mah ] a focal malignant tumor composed of myeloblasts or early myeloid precursors occurring outside of the bone marrow; observed in acute myelogenous leukemia .